6-(trifluoromethoxy) quinolin-2(1H)-one is an organic compound with the chemical formula C10H5F3NO2. The following is a detailed description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: 6-(trifluoromethoxy) quinolin-2(1H)-one is a white to pale yellow crystalline solid.
-Solubility: It has good solubility in common organic solvents (such as ethanol, chloroform and dichloromethane) and is slightly soluble in water.
-Melting point: Its melting point range is generally between 70°C and 75°C.
Use:
- 6-(trifluoromethoxy) quinolin-2(1H)-one is an intermediate used in the synthesis of drugs and pesticides. Such compounds are widely used in the field of medicine for the research and development of drugs with antitumor, antiviral and antimicrobial activities.
-It can also be used as an intermediate for photosensitive dyes, coatings, rubber and plastic additives.
Preparation Method:
The preparation of - 6-(trifluoromethoxy) quinolin-2(1H)-one usually involves the reaction of 2-aminoquinoline with trifluoromethane anhydride to generate the corresponding amide intermediate, and then oxidation or deprotection reaction under appropriate reaction conditions to obtain the target compound.
Safety Information:
- 6-(trifluoromethoxy) quinolin-2(1H)-one has no special safety risks under normal operation.
-Use should follow proper laboratory procedures and take appropriate personal protective measures, such as wearing gloves and safety glasses.
-When storing and handling this compound, take care to avoid contact with oxidants and strong acids to prevent fire or explosion.
-Detailed safety information and operating instructions can be obtained through the safety data sheet (SDS) of the chemical supplier.